SCI

19July

Pathophysiology,Transmission,Diagnosis,andTreatmentofCoronavirusDisease(COVID-19):AReview

WiersingaWJoost,RhodesAndrew,ChengAllenCetal.Pathophysiology,Transmission,Diagnosis,andTreatmentofCoronavirusDisease(COVID-19):AReview.[J].JAMA,,undefined:undefined.

IMPORTANCE重要性

Thecoronavirusdisease(COVID-19)pandemic,duetothenovelsevereacuterespiratorysyndromecoronavirus2(SARS-CoV-2),hascausedaworldwidesuddenandsubstantialincreaseinhospitalizationsforpneumoniawithmultiorgandisease.Thisreviewdiscussescurrentevidenceregardingthepathophysiology,transmission,diagnosis,andmanagementofCOVID-19.

由于新型严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)，年(新冠肺炎)冠状病毒大流行已导致全球因肺炎合并多器官疾病住院人数突然大幅增加。该综述讨论了新冠肺炎的病理生理、传播、诊断和治疗方面的现有证据。

Observations观察

SARS-CoV-2isspreadprimarilyviarespiratorydropletsduringcloseface-to-facecontact.Infectioncanbespreadbyasymptomatic,presymptomatic,andsymptomaticcarriers.Theaveragetimefromexposuretosymptomonsetis5days,and97.5%ofpeoplewhodevelopsymptomsdosowithin11.5days.Themost